Non-Kolbe electrolysis of N-protected-α-amino acids: a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines
Data
2022-01-12Autor
Walęcka-Kurczyk, A.
Adamek, J.
Walczak, K.
Michalak, M.
Październiok-Holewa, A.
Metadane
Pokaż pełny rekordStreszczenie
Here, we report a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produced the products in excellent yields above 90%.
Kolekcje
- Artykuły IChO PAN [112]