Propargylation of CoQ0 through the Redox Chain Reaction

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Authors
Pawlowski, Robert
Stodulski, Maciej
Mlynarski, Jacek
Date
2022-01
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Publisher
American Chemical Society
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Abstract
An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect of Sc(OTf)3 and Hantzsch ester. It is suggested to work through the redox chain reaction, which involves hydroquinone and dimeric propargylic moiety intermediates. A broad range of propargylic alcohols can be converted into the appropriate derivatives of CoQ0 containing triple bonds in good to excellent yields. The mechanism of the given transformation is also discussed.
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Keywords
alcohols    chemical reactions    lipids    mixtures    redox reactions
Citation
J. Org. Chem. 2022, 87, 683−692. https://doi.org/10.1021/acs.joc.1c02685
URI
https://depot.ceon.pl/handle/123456789/21372
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