Hydrogen-bonded supramolecular assemblies of folic acid with simple hexoses

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Authors
Ceborska, Magdalena
Dąbrowa, Kajetan
Cędrowski, Jakub
Zimnicka, Magdalena
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
License
Creative Commons License
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Abstract
Simple D-hexoses such as D-glucose, D-mannose, and D-galactose were found to form supramolecular complexes with folic acid (FA) in phosphate-buffered saline solution (PBS, pH 7.4) and in the gas phase. Pterin subunit of FA was found to be essential for the molecular assembly with hexoses, whereas PABA (p-amino benzoic acid) and GLN (glutamic acid) subunits of FA have virtually no effect on assembly formation. Experimental measurements along with DFT theoretical calculations reveal that hexose-FA assemblies are stabilized by three complementary hydrogen bonds between pterin subunit of FA and 3,4,6-trihydroxyl moiety of hexose.
Description
Keywords
folic acid    monosaccharides    hydrogen bonded associates    supramolecular chemistry
Citation
Ceborska, M., Dąbrowa, K.,Cędrowski, J., Zimnicka, M. (2022). Hydrogen-bonded supramolecular assemblies of folic acid with simple hexoses. Journal of Molecular Structure: 1250, Part 3, 131904. https://doi.org/10.1016/j.molstruc.2021.131904
URI
https://depot.ceon.pl/handle/123456789/21596
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