DCC Mediated Direct Amidation of NSAID Naproxen, Ibuprofen and Ketoprofen with Secondary Amines

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Authors
Mart, Mehmet
Karakaya, Idris
Jurczak, Janusz
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
License
Creative Commons License
Creative Commons Attribution 4.0 International License
Abstract
Direct and atom-economical amidation of nonsteroidal anti-inflammatory drugs naproxen ibuprofen and ketoprofen with a variety of secondary amines was effected using commercially available DCC under mild and open-air conditions. These prodrug amides were obtained in good to moderate yields ranging between 30–90 %.
Description
Keywords
direct amidation    NSAID    secondary amine    naproxen    ibuprofen    ketoprofen
Citation
Chemistry Select 2022, 7, e202202436 (1 of 5) ; https://doi.org/10.1002/slct.202202436
URI
https://depot.ceon.pl/handle/123456789/22314
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Artykuły IChO PAN