Stressful Events and Serum Concentration of Substance P in Acne Patients
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Data
2016Autor
Rokowska-Waluch, Anita
Pawlaczyk, Mariola
Cybulski, Marcin
Żurawski, Jakub
Kaczmarek, Mariusz
Michalak, Michał
Mojs, Ewa
Metadane
Pokaż pełny rekordStreszczenie
Background: Psychological stress is an important factor of
acne pathogenesis. Stress related production of hormones,
cytokines and neuropeptides may result in the chronic
course and exacerbations of the disease. Objective: The aim
of the study was to evaluate the relationship between acne
severity, intensity of emotional stress and serum concen
tration of substance P (scSP), to compare the intensity of ad
versities, psychological stress and scSP in acne patients with
healthy controls and to compare coping techniques for
stress. Methods: The study consisted of 80 patients. Emotio
nal stress was analyzed with the use of social readjustment
rating scale, whereas the methods of coping with stress were
assessed with the coping inventory for stressful situation
questionnaire. The blood concentration of substance P was
analyzed by enzyme-linked immunosorbent assay method
in a group of 40 patients with acne vulgaris and in control
subjects. Results: There was no statistically significant differ
ence between the severity of acne and the intensity of stress.
Acne patients presented a higher average scSP than the
controls. No statistically significant correlation was observed
between the severity of acne and scSP; however, the in
tensity of stress correlated with scSP in the control group. Theevaluation of methods of coping with stress showed sig
nificantly higher rate for the avoidance-oriented coping
among acne patients. Conclusion: The number of stressful
events is not a factor that determines the severity of acne. The
course of the disease may depend on tolerance to stress and
methods of coping with stress. (Ann Dermatol 28(4) 464∼
469, 2016)
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