Przeglądaj Instytut Chemii Fizycznej PAN według autora "Bielec, Krzysztof"
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Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude
Kowalski, Adam; Bielec, Krzysztof; Bubak, Grzegorz; Żuk, Paweł J.; Czajkowski, Maciej; Sashuk, Volodymyr; Huck, Wilhelm T. S.; Antosiewicz, Jan M.; Hołyst, Robert (Springer Nature, 2022-10-28)The reaction kinetics between like-charged compounds in water is extremely slow due to Coulomb repulsions. Here, we demonstrate that by screening these interactions and, in consequence, increasing the local concentration ... -
Ion Complexation Explains Orders of Magnitude Changes in the Equilibrium Constant of Biochemical Reactions in Buffers Crowded by Nonionic Compounds
Bielec, Krzysztof; Kowalski, Adam; Bubak, Grzegorz; Witkowska Nery, Emilia; Hołyst, Robert (ASC Publications, 2022-01-13)The equilibrium constant (K) of biochemical complex formation in aqueous buffers with high concentration (>20 wt %) of nonionic compounds can vary by orders of magnitude in comparison with the K in a pure buffer. The precise ... -
Single-molecule brightness analysis for the determination of anticancer drug interactions with DNA
Zhou, Ying; Bielec, Krzysztof; Pasitsuoaroad, Pakorn; Hołyst, Robert (Royal Society of Chemistry, 2020)Anthracyclines are one of the most studied anticancer drugs approved for medical treatment. The equilibrium constant (K) of the reaction between these drugs with DNA in both in vitro and in vivo experiments lacks consensus. ...