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Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162
(American Chemical Society, 2021-12-03)
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration associated with amyloid β (Aβ) peptide aggregation. The aggregation of Aβ monomers (AβMs) leads to the formation of Aβ oligomers (AβOs), the ...
Alzheimer's disease-related amyloid β peptide causes structural disordering of lipids and changes the electric properties of a floating bilayer lipid membrane
(Royal Society of Chemistry, 2020-06-27)
Neurodegeneration in Alzheimer's disease is associated with disruption of the neuronal cell membrane by the amyloid β (Aβ) peptide. However, the disruption mechanism and the resulting changes in membrane properties remain ...
Nanomechanical characterization of single phospholipid bilayer in ripple phase with PF-QNM AFM
(Elsevier B.V., 2020-05-07)
Topography and nanomechanical properties of the supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) single bilayer in the ripple phase were investigated by atomic force microscopy with the use of PeakForce ...
Size-Dependent Interaction of Amyloid β Oligomers with Brain Total Lipid Extract Bilayer - Fibrillation Versus Membrane Destruction
(American Chemical Society, 2019-07-21)
Amyloid β, Aβ(1-42), is a component of senile plaques present in the brain of Alzheimer's disease patients and one of the main suspects responsible for pathological consequences of the disease. Herein, we directly visualize ...
Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β?
(Elsevier B.V., 2022-01-21)
Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is followed by aggregation via different ...