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Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162
(American Chemical Society, 2021-12-03)
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration associated with amyloid β (Aβ) peptide aggregation. The aggregation of Aβ monomers (AβMs) leads to the formation of Aβ oligomers (AβOs), the ...
Alzheimer's disease-related amyloid β peptide causes structural disordering of lipids and changes the electric properties of a floating bilayer lipid membrane
(Royal Society of Chemistry, 2020-06-27)
Neurodegeneration in Alzheimer's disease is associated with disruption of the neuronal cell membrane by the amyloid β (Aβ) peptide. However, the disruption mechanism and the resulting changes in membrane properties remain ...
Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β?
(Elsevier B.V., 2022-01-21)
Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the major event associated with Alzheimer's disease's neurotoxicity. Misfolding of amyloid β is followed by aggregation via different ...