Browsing Instytut Chemii Organicznej PAN by Issue Date
Now showing items 1-20 of 74
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On-Surface Azide–Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts?
(American Chemical Society, 2022)Owing to its simplicity, selectivity, high yield, and the absence of byproducts, the “click” azide–alkyne reaction is widely used in many areas. The reaction is usually catalyzed by copper(I), which selectively produces ... -
Multifunctional Heteropentalenes: From Synthesis to Optoelectronic Applications
(American Chemical Society, 2022)In the broad family of heteropentalenes, the combination of two five-membered heterocyclic rings fused in the [3,2-b] mode has attracted the most significant attention. The relatively straightforward access to these ... -
The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes
(MDPI, 2022)Herein, we present biological studies on 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now, DHPMs have not been tested for biological activity ... -
Effect of amide protoporphyrin derivatives on immune response in Apis mellifera
(Springer Nature, 2022)The intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling ... -
Copolymers Containing 1-Methyl-2-phenyl-imidazole Moieties as Permanent Dipole Generating Units: Synthesis, Spectroscopic, Electrochemical, and Photovoltaic Properties
(MDPI, 2022)New donor–acceptor conjugated alternating or random copolymers containing 1-methyl-2- phenylbenzimidazole and benzothiadiazole (P1), diketopyrrolopyrrole (P4), or both acceptors (P2) are reported. The specific feature of ... -
Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains
(MDPI, 2022)An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good ... -
Changes in the mitochondrial membrane potential in endothelial cells can be detected by Raman microscopy
(Elsevier, 2022)The role of mitochondria goes beyond their capacity to create molecular fuel and includes e.g. the production of reactive oxygen species and the regulation of cell death. In endothelial cells, mitochondria have a significant ... -
Network search algorithms and scoring functionsfor advanced-level computerized synthesis planning
(Wiley, 2022)In 2020, a“hybrid”expert-AI computer program called Chematica (a.k.a. Synthia)was shown to autonomously plan multistep syntheses of complex natural prod-ucts, which remain outside the reach of purely data-driven AI programs. ... -
Room-Temperature-Stable Magnesium Electride via Ni(II) Reduction
(American Chemical Society, 2022)Herein, we report the synthesis of highly reduced bipyridyl magnesium complexes and the first example of a stable organic magnesium electride supported by quantum mechanical computations and X-ray diffraction. These complexes ... -
Site-Selective, Photocatalytic Vinylogous Amidation of Enones
(American Chemical Society, 2022)Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation ... -
A Unique and Stable Polyproline I Helix Sorted out from Conformational Equilibrium by Solvent Polarity
(American Chemical Society, 2022)Polyproline I helical structures are often considered as the hidden face of their most famous geminal sibling, Polyproline II, as PPI is generally spotted only within a conformational equilibrium. We designed and synthesized ... -
C−C Bond Forming Reactions Enabled by Vitamin B12 - Opportunities and Challenges
(American Chemical Society, 2022)Cobalt not only is an essential micronutrient for mammals but also marks itself as important in organic synthesis, especially in the field of catalysis. Various useful reactions, such as alkene hydroformylation, hydrogenation, ... -
Spatially resolved chiroptical study of thin films ofbenzo[1,2-b:4,5-b’]dithiophene-based oligothiophenes bysynchrotron radiation electronic circular dichroism imaging(SR-ECDi) technique
(Wiley, 2022)The study of the chiroptical properties of thin-film samples of two chiral benzo[1,2-b:4,5-b’]dithiophene-based oligothiophenes with optoelectronic properties was car-ried out at Diamond B23 beamline using the synchrotron ... -
A Holistic Approach to Determining Stereochemistry of Potential Pharmaceuticals by Circular Dichroism with β-Lactams as Test Cases
(MDPI, 2022)This paper’s main objective is to show that many different factors must be considered when solving stereochemical problems to avoid misleading conclusions and obtain conclusive results from the analysis of spectroscopic ... -
H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters
(MDPI, 2022)In this work, we would like to present the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters. This enantioselective phase-transfer alkylation catalyzed by hybrid ... -
Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates
(MDPI, 2022)An enzymatic route for phosphorous–carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant ... -
Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik−Fields Reaction
(MDPI, 2022)We reported a new method dealing with the synthesis of novel pharmacologically relevant α-aminophosphonate derivatives via a lipase-catalyzed Kabachnik−Fields reaction with yields of up to 93%. The advantages of this ... -
Electronic Circular Dichroism Imaging (ECDi) Casts a New Light on the Origin of Solid-State Chiroptical Properties
(Wiley, 2022)Solid-state ECD (ss-ECD) spectra of a model microcrystalline solid, finasteride, dispersed into a KCl pellet were recorded by using the synchrotron radiation source at the Diamond B23 beamline. Scanning a surface of 36 mm2 ... -
EdU sensing: The Raman way of following endothelial cell proliferation in vitro and ex vivo
(Elsevier, 2022)Endothelial cells line the lumen of all vessels in the body and maintain vascular homeostasis. In particular, endothelial cell regeneration in response to insult sustain functional endothelial layer. EdU (5-ethynyl-2′-de ... -
All-Polymer Microcavities for the Fluorescence Radiative Rate Modification of a Diketopyrrolopyrrole Derivative
(American Chemical Society, 2022)Controlling the radiative rate of emitters with macromolecular photonic structures promises flexible devices with enhanced performances that are easy to scale up. For instance, radiative rate enhancement empowers low-threshold ...