Przeglądaj Instytut Chemii Organicznej PAN według daty wydania
Wyświetlanie pozycji 1-20 z 111
-
DCC Mediated Direct Amidation of NSAID Naproxen, Ibuprofen and Ketoprofen with Secondary Amines
(Wiley, 2022)Direct and atom-economical amidation of nonsteroidal anti-inflammatory drugs naproxen ibuprofen and ketoprofen with a variety of secondary amines was effected using commercially available DCC under mild and open-air ... -
Insight on the Interaction between the Camptothecin Derivative and DNA Oligomer Mimicking the Target of Topo I Inhibitors
(MDPI, 2022)The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and safe pharmaceuticals in oncological chemotherapy. The vast ... -
Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
(American Chemical Society, 2022)The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide ... -
Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains
(MDPI, 2022)An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good ... -
Recent advances in the application of nanoparticles in the selective reduction of carbon–carbon double bonds
(Elsevier, 2022)Herein, we present recent advances in the application of metal nanoparticles in the selective hydrogenation of C–C double bonds. The review focuses on reduction methods of alkenes, arenes, and aromatic heterocycles, which ... -
Ruthenium Olefin Metathesis Catalysts Bearing a Macrocyclic N-Heterocyclic Carbene Ligand: Improved Stability and Activity
(Wiley, 2022)Formation of sterically hindered C−C double bonds via catalytic olefin metathesis is considered a very challenging task for Ru catalysts. This limitation led to the development of specialised catalysts bearing sterically ... -
Path-dependency of energy decomposition analysis & the elusive nature of bonding
(Royal Society of Chemistry, 2022)Here, we provide evidence of the path-dependency of the energy components of the energy decomposition analysis scheme, EDA, by studying a set of thirty-one closed-shell model systems with the D2h symmetry point group. For ... -
Toward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centers
(American Chemical Society, 2022)Tripodal chiral ligands containing amino acid residues and salicyl-acylhydrazone units were synthesized and used to obtain coordination cages through deprotonation and coordination to gallium. These coordination cages have ... -
Ligand-to-metal ratio controls stereoselectivity: Highly functional-group-tolerant, iridium-based, (E)-selective alkyne transfer semihydrogenation
(Elsevier, 2022)Herein, we present (E)-selective transfer semihydrogenation of al kynes based on an iridium complex in situ generated from [Ir(COD)Cl]2 and an unsymmetrical (bearing two different phosphorous cen ters), ferrocene-based ... -
Wheat germ lipase: isolation, purification and applications
(Taylor and Francis, 2022)In recent years, wheat germ lipase (WGL) is attracting considerable interest. To date, several WGL applications have already been described: (i) fats and oils modification; (ii) esterification reactions in organic media, ... -
Recognition-Induced Enhanced Emission of Core-Fluorescent ESIPT-type Macrocycles
(Wiley, 2022)Core-fluorescent cavitandsbased on 2-(2′-resorcinol)benzimidazole fluorophores (RBIs)merged with the resorcin[4]arene skeleton were designed and synthesized. The cavitands, due to the presence of intramolecular ... -
Porphyrins as Promising Photocatalysts for Red-Light-Induced Functionalizations of Biomolecules
(American Chemical Society, 2022)Red-light enables deeper material penetration, which is important for biological applications and has consequences for chemical synthesis. Therefore, the search for new photocatalysts that absorb in this region is crucial. ... -
Selective Approaches to α- and β-Arylated Vinyl Ethers
(Wiley, 2022)We developed simple and efficient protocols for palladium-catalyzed regioselective a- and b-arylations of structurally diverse vinyl ethers. Both catalytic methods proceed under relatively mild reactions conditions ... -
Pyridine N-oxides as HAT reagents for photochemical C–H functionalization of electron-deficient heteroarenes
(Royal Society of Chemistry, 2022)Pyridine N-oxides have only recently marked their presence in the photocatalysis field, mainly serving as oxypyridinium salt precursors. Herein, their unique reactivity as a hydrogen atom transfer reagent in photochemical, ... -
Effect of amide protoporphyrin derivatives on immune response in Apis mellifera
(Springer Nature, 2022)The intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling ... -
A Holistic Approach to Determining Stereochemistry of Potential Pharmaceuticals by Circular Dichroism with β-Lactams as Test Cases
(MDPI, 2022)This paper’s main objective is to show that many different factors must be considered when solving stereochemical problems to avoid misleading conclusions and obtain conclusive results from the analysis of spectroscopic ... -
H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters
(MDPI, 2022)In this work, we would like to present the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters. This enantioselective phase-transfer alkylation catalyzed by hybrid ... -
Multifunctional Heteropentalenes: From Synthesis to Optoelectronic Applications
(American Chemical Society, 2022)In the broad family of heteropentalenes, the combination of two five-membered heterocyclic rings fused in the [3,2-b] mode has attracted the most significant attention. The relatively straightforward access to these ... -
On-Surface Azide–Alkyne Cycloaddition Reaction: Does It Click with Ruthenium Catalysts?
(American Chemical Society, 2022)Owing to its simplicity, selectivity, high yield, and the absence of byproducts, the “click” azide–alkyne reaction is widely used in many areas. The reaction is usually catalyzed by copper(I), which selectively produces ... -
Triptycene Derivatives: From Their Synthesis to Their Unique Properties
(MDPI, 2022)Since the first preparation of triptycene, great progress has been made with respect to its synthesis and the understanding of its properties. Interest in triptycene-based systems is intense; in recent years, advances ...