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Promiscuous Lipase-Catalyzed Knoevenagel–Phospha–Michael Reaction for the Synthesis of Antimicrobial β-Phosphono Malonates 

Samsonowicz-Górski, Jan; Koszelewski, Dominik; Kowalczyk, Paweł; Śmigielski, Paweł; Hrunyk, Anastasiia; Kramkowski, Karol; Wypych, Aleksandra; Szymczak, Mateusz; Lizut, Rafał; Ostaszewski, Ryszard (MDPI, 2022)
An enzymatic route for phosphorous–carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a new metal-free biocatalytic method for the synthesis of pharmacologically relevant ...
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Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik−Fields Reaction 

Koszelewski, Dominik; Kowalczyk, Paweł; Śmigielski, Paweł; Samsonowicz-Górski, Jan; Kramkowski, Karol; Wypych, Aleksandra; Szymczak, Mateusz; Ostaszewski, Ryszard (MDPI, 2022)
We reported a new method dealing with the synthesis of novel pharmacologically relevant α-aminophosphonate derivatives via a lipase-catalyzed Kabachnik−Fields reaction with yields of up to 93%. The advantages of this ...
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Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains 

Sahrawat, Parul; Kowalczyk, Paweł; Koszelewski, Dominik; Szymczak, Mateusz; Kramkowski, Karol; Wypych, Aleksandra; Ostaszewski, Ryszard (MDPI, 2022)
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good ...
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The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents 

Brodzka, Anna; Kowalczyk, Paweł; Trzepizur, Damian; Koszelewski, Dominik; Kramkowski, Karol; Szymczak, Mateusz; Wypych, Aleksandra; Lizut, Rafał; Ostaszewski, Ryszard (MDPI, 2022)
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on cytotoxic activity was studied. The organophosphonates were obtained based on developed palladium-catalyzed α, β-homodiarylation of vinyl ...
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Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to Benzoquinones 

Koszelewski, Dominik; Kowalczyk, Paweł; Samsonowicz-Górski, Jan; Hrunyk, Anastasiia; Brodzka, Anna; Łęcka, Justyna; Kramkowski, Karol; Ostaszewski, Ryszard (MDPI, 2023)
A mild and efficient protocol for the synthesis of p-quinols under aqueous conditions was developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and heteroaryl boronic acids to benzoquinones ...
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Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to Benzoquinones 

Koszelewski, Dominik; Kowalczyk, Paweł; Samsonowicz-Górski, Jan; Hrunyk, Anastasiia; Brodzka, Anna; Łęcka, Justyna; Kramkowski, Karol; Ostaszewski, Ryszard (MDPI, 2023)
A mild and efficient protocol for the synthesis of p-quinols under aqueous conditions was developed. The pivotal role of additives in the copper-catalyzed addition of aryl boronic and heteroaryl boronic acids to benzoquinones ...

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AuthorKoszelewski, Dominik (6)Kowalczyk, Paweł (6)Kramkowski, Karol (6)Ostaszewski, Ryszard (6)Samsonowicz-Górski, Jan (4)... View MoreAffiliationDepartment of Physical Chemistry, Medical University of Bialystok (6)Institute of Organic Chemistry, Polish Academy of Sciences (6)Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences (5)... View MoreSubject
antimicrobial activity (6)
E. coli cells (3)additives (2)chemoselectivity (2)copper metal–organic frameworks (Cu-MOF) (2)... View MoreDate Issued2022 (4)2023 (2)LicenseCreative Commons Uznanie autorstwa 4.0 (5)Uznanie autorstwa 3.0 Polska (1)

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