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Wyświetlanie pozycji 11-20 z 85
The Evaluation of DHPMs as Biotoxic Agents on Pathogen Bacterial Membranes
(MDPI, 2022)
Herein, we present biological studies on 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) obtained via Biginelli reaction catalyzed by NH4Cl under solvent-free conditions. Until now, DHPMs have not been tested for biological activity ...
Effect of amide protoporphyrin derivatives on immune response in Apis mellifera
(Springer Nature, 2022)
The intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling ...
From Flask to Mill: Reductive Functionalization of Fluoroacetamides as a Case Study for Transferring Solvent-Based Reactions to the Solid State
(American Chemical Society, 2022)
The development of sustainable methods is a central focus of modern organic synthesis and has applications in various areas of the chemical industry. Mechanochemistry is a highly desirable green synthetic method as it ...
Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives
(MDPI, 2022-03-07)
An enzymatic route for phosphorous-carbon- bond formation is developed by discovering
new promiscuous activity of lipase. This biocatalytic transformation of phosphorous-carbon- bond
addition leads to biologically and ...
C−C Bond Forming Reactions Enabled by Vitamin B12 - Opportunities and Challenges
(American Chemical Society, 2022)
Cobalt not only is an essential micronutrient for mammals but also marks itself as important in organic synthesis, especially in the field of catalysis. Various useful reactions, such as alkene hydroformylation, hydrogenation, ...
A Modular Approach to Atropisomeric Bisphosphines of Diversified Electronic Density on Phosphorus Atoms
(MDPI, 2022)
The series of C2-symmetric biaryl core-based non-racemic bisphosphines possessing substituents of different electronic properties: both EDG and EWG were obtained in a short sequence of good yielding transformations, started ...
From truxenes to heterotruxenes: playing with heteroatoms and the symmetry of molecules
(Royal Society of Chemistry, 2022-03-24)
The truxene molecule is more versatile and widespread than ever imagined. At the end of the last century, this star-shaped structure was recognized mostly in liquid crystals. However, the development of optoelectronics ...
Diastereoselective Formation of Quaternary Stereocenters in Imidazole N-Oxide Cycloaddition with Fluoroalkenes
(MDPI, 2022)
Imidazole N-oxides are attractive starting materials for the preparation of complex molecules containing an imidazole ring. Dipolar cycloaddition between 1,1-difluoroalkenes and imidazole N-oxides bearing a chiral auxiliary ...
The Synthesis and Evaluation of Diethyl Benzylphosphonates as Potential Antimicrobial Agents
(MDPI, 2022)
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on cytotoxic activity was studied. The organophosphonates were obtained based on developed palladium-catalyzed α, β-homodiarylation of vinyl ...
Electronic Circular Dichroism Imaging (ECDi) Casts a New Light on the Origin of Solid-State Chiroptical Properties
(Wiley, 2022)
Solid-state ECD (ss-ECD) spectra of a model microcrystalline solid, finasteride, dispersed into a KCl pellet were recorded by using the synchrotron radiation source at the Diamond B23 beamline. Scanning a surface of 36 mm2 ...