Szukaj
Wyświetlanie pozycji 1-10 z 69
DCC Mediated Direct Amidation of NSAID Naproxen, Ibuprofen and Ketoprofen with Secondary Amines
(Wiley, 2022)
Direct and atom-economical amidation of nonsteroidal anti-inflammatory drugs naproxen ibuprofen and ketoprofen with a variety of secondary amines was effected using commercially available DCC under mild and open-air ...
Insight on the Interaction between the Camptothecin Derivative and DNA Oligomer Mimicking the Target of Topo I Inhibitors
(MDPI, 2022)
The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and safe pharmaceuticals in oncological chemotherapy. The vast ...
Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin
(American Chemical Society, 2022)
The natures of electron-donating groups as well as the bridge between them determine the fate of substituted 1,8-naphthalimide molecules in the excited state. An activity-based probe constructed from a selective peptide ...
Photocatalysis in Aqueous Micellar Media Enables Divergent C–H Arylation and N-Dealkylation of Benzamides
(American Chemical Society, 2022-03-04)
Photocatalysis in aqueous micellar media has
recently opened wide avenues to activate strong carbon−halide
bonds. So far, however, it has mainly explored strongly reducing
conditions, restricting the available chemical ...
Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains
(MDPI, 2022)
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good ...
Recent advances in the application of nanoparticles in the selective reduction of carbon–carbon double bonds
(Elsevier, 2022)
Herein, we present recent advances in the application of metal nanoparticles in the selective hydrogenation of C–C double bonds. The review focuses on reduction methods of alkenes, arenes, and aromatic heterocycles, which ...
Ruthenium Olefin Metathesis Catalysts Bearing a Macrocyclic N-Heterocyclic Carbene Ligand: Improved Stability and Activity
(Wiley, 2022)
Formation of sterically hindered C−C double bonds via catalytic olefin metathesis is considered a very challenging task for Ru catalysts. This limitation led to the development of specialised catalysts bearing sterically ...
Path-dependency of energy decomposition analysis & the elusive nature of bonding
(Royal Society of Chemistry, 2022)
Here, we provide evidence of the path-dependency of the energy components of the energy decomposition analysis scheme, EDA, by studying a set of thirty-one closed-shell model systems with the D2h symmetry point group. For ...
Toward Coordination Cages with Hybrid Chirality: Amino Acid-Induced Chirality on Metal Centers
(American Chemical Society, 2022)
Tripodal chiral ligands containing amino acid residues and salicyl-acylhydrazone units were synthesized and used to obtain coordination cages through deprotonation and coordination to gallium. These coordination cages have ...
Ligand-to-metal ratio controls stereoselectivity: Highly functional-group-tolerant, iridium-based, (E)-selective alkyne transfer semihydrogenation
(Elsevier, 2022)
Herein, we present (E)-selective transfer semihydrogenation of al kynes based on an iridium complex in situ generated from [Ir(COD)Cl]2 and an unsymmetrical (bearing two different phosphorous cen ters), ferrocene-based ...