dc.contributor.author | Niedbała, Patryk | |
dc.contributor.author | Majdecki, Maciej | |
dc.contributor.author | Grodek, Piotr | |
dc.contributor.author | Jurczak, Janusz | |
dc.date.accessioned | 2022-06-24T12:20:34Z | |
dc.date.available | 2022-06-24T12:20:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Niedbała, P.; Majdecki, M.;Grodek, P.; Jurczak, J. H-Bond Mediated Phase-Transfer Catalysis: Eantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters. Molecules 2022, 27, 2508. https://doi.org/10.3390/molecules27082508 | en |
dc.identifier.issn | 1420-3049 | |
dc.identifier.other | 10.3390/molecules27082508 | |
dc.identifier.uri | https://depot.ceon.pl/handle/123456789/21379 | |
dc.description.abstract | In this work, we would like to present the development of a highly optimized method for generating the quaternary stereogenic centers in β-keto esters. This enantioselective phase-transfer alkylation catalyzed by hybrid Cinchona catalysts allows for the efficient generation of the optically active products with excellent enantioselectivity, using only 1 mol% of the catalyst. The vast majority of phase-transfer catalysts in asymmetric synthesis work by creating ionic pairs with the nucleophile-attacking anionic substrate. Therefore, it is a sensible approach to search for new methodologies capable of introducing functional groups into the precursor’s structure, maintaining high yields and enantiomeric purity. | en |
dc.description.sponsorship | National Science Center, Poland (grant: 2018/29/B/ST5/01366) | |
dc.language.iso | en | |
dc.publisher | MDPI | en |
dc.rights | Creative Commons Uznanie autorstwa 4.0 | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/legalcode | * |
dc.subject | phase-transfer catalysis | en |
dc.subject | organocatalysis | en |
dc.subject | enantioselectivity | en |
dc.subject | Cinchona catalysts | en |
dc.subject | alkylation | en |
dc.title | H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters | en |
dc.type | article | en |
dc.contributor.organization | Institute of Organic Chemistry, Polish Academy of Sciences | en |