The Reaction of Rat Kidney to Acute Stress Solution of Sodium Chloride in Normal and Occasional Abuse of Thyroid Status

Abstract

Objective: To study the effectiveness of osmoregulation of renal function in rats with occasional violation of thyroid status in the acute intragastric load of sodium chloride solutions. Materials and Methods: The study was carried out on white male rats, thyroxine was administered once intraperitoneally, 50 mg/100 g body weight. Kidney function was studied in conditions induced diuresis after intragastric administration of stress testing water or 0.3%, 0.8%, 2% and 3% sodium chloride solution in a volume of 5% of body weight. Results: It was found that thyroxin causes a decrease in creatinine clearance and increased renal excretion of endogenous nitrates and nitrites. In control solutions, increasing concentrations of sodium chloride cause progressive increase in glomerular filtration rate values and excretion of osmotically active substances. Discovered a more complex dependence of the values of diuresis and the concentration of NaCl. Minimum performance diuresis recorded using a solution of 0.8% NaCl, and the maximum - in load and aqueous 3% solution of NaCl. Conclusions: 1. The kidneys of rats administered once T4 retain the ability excretion of excessive amounts of liquid and OAB, protecting the internal tissues and organs from hypoosmia and hyperosmotic stress. 2. A single dose of T4 rats can induce switching mechanisms of renal volume regulation and osmoregulation in the phylogenetically ancient tubular type of regulation of fluid excretion by the kidneys and the OAB. 3. For short abuse thyroid status changes in GFR and tubular transport OAB are reversible.