Intramyocardial Transplantation of Peripheral Progenitor Cells in Patients With Ischemic Cardiomyopathy and Carriage of the 4g/5g Polymorfism of Plasminogen Activator Inhibitor Type 1 Gene (Pai-1)

Abstract

Abstract. The article reflects the influence of 4G/5G polymorphism of the plasminogen activator inhibitor type 1 gene (PAI-1) on the progression of congestive heart failure (CHF) and ischemic cardiomyopathy (ICMP). Indications for intramyocardial transplantation of peripheral blood stem cells (PBSC), depending on the carriage of different PAI-1 alleles were determined. The study comprises 45 patients with ICMP, who are resistant to standard medical therapy and for whom surgical treatments are contraindicated (or were not effective). The patients were divided into 2 groups: in group 1 (n =15) intramyocardial PBSC transplantation was performed, group 2 (n=30) underwent a standard drug therapy. 4G/5G polymorphism PAI-1was determined for all the participants of the study. The results showed that the carriage of 4G/4G polymorphism PAI-1 is a predictor of severe progression of congestive heart failure and a risk factor for the development of ICMP. It is recommended to perform intramyocardial PBSC transplantation to the patients of the study as early as possible.