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Diffusion in crowded biological environments: applications of Brownian dynamics
(BioMed Central, 2011-03-02)
Biochemical reactions in living systems occur in complex, heterogeneous media with total concentrations of macromolecules in the range of 50 - 400 mg/ml. Molecular species occupy a significant fraction of the immersing ...
Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site
(PLOS, 2011-08-16)
In hospitals throughout the world, aminoglycosidic antibiotics are used to combat even the most severe bacterial infections. However, the continuous emergence of resistant bacteria has created an urgent need to improve ...
Molecular dynamics of ribosomal elongation factors G and Tu
(Springer Nature, 2011)
Translation on the ribosome is controlled by external factors. During polypeptide lengthening, elongation factors EF-Tu and EF-G consecutively interact with the bacterial ribosome. EF-Tu binds and delivers an aminoacyl-tRNA ...