Internal capsule integrity and its sex-related structural differences in early-onset schizophrenia – diffusion tensor imaging study
Oglądaj/ Otwórz
Data
2015Autor
Gawłowska-Sawosz, Marta
Rabe-Jabłońska, Jolanta
Gębski, Piotr
Chomczyński, Piotr Andrzej
Metadane
Pokaż pełny rekordStreszczenie
Objectives: In schizophrenia, the most repeatable DTI findings concern reduced FA in
temporal and frontal lobes with associated abnormalities in connecting neural fibers. The goal of
study was to evaluate the differences in FA of the internal capsule in EOS-patients and healthy
controls and to place emphasis on the sex as a potential factor determining a predominant
pathological pattern of described changes.
Methods: 30 EOS patients and 30 healthy controls were studied using DTI. FA measures
within internal capsules were performed in selected ROIs. For statistical analyses the one-way
ANOVA test was used (p<0.05).
Results: Significant differences of FA between EOS-patients and controls in the right ALIC
with lower values of FA in EOS were observed. Within the women sub-groups, statistical differences
of FA were observed only for the right ALIC. There were no statistically significant
differences within men sub-groups.
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