Przeglądaj Artykuły IChO PAN według autora "Gryko, Dorota"
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Aryl versus Alkyl Redox-Active Diazoacetates ─ Light-Induced C–H Insertion or 1,2-Rearrangement
Santiago, João V.; Orłowska, Katarzyna; Ociepa, Michał; Gryko, Dorota (American Chemical Society, 2023)Diazo compounds with redox-active leaving groups are versatile reagents for orthogonal functionalizations, previously utilized in the Rh-catalyzed synthesis of highly substituted cyclopropanes. Photochemical activation of ... -
Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes
Potrząsaj, Aleksandra; Ociepa, Michał; Chaładaj, Wojciech; Gryko, Dorota (American Chemical Society, 2022-03-25)Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we ... -
C−C Bond Forming Reactions Enabled by Vitamin B12 - Opportunities and Challenges
Wdowik, Tomasz; Gryko, Dorota (American Chemical Society, 2022)Cobalt not only is an essential micronutrient for mammals but also marks itself as important in organic synthesis, especially in the field of catalysis. Various useful reactions, such as alkene hydroformylation, hydrogenation, ... -
C−H Functionalization of Heterocycles with Triplet Carbenes by means of an Unexpected 1,2-Alkyl Radical Migration
Empel, Claire; Jana, Sripati; Ciszewski, Łukasz W.; Zawada, Katarzyna; Pei, Chao; Gryko, Dorota; Koenigs, Rene M. (Wiley, 2023)The C−H functionalization of indole heterocycles constitutes a key strategy to leverage the synthesis of endogenous signaling molecules such as tryptamine or tryptophol. Herein, we report on the photocatalytic reaction of ... -
Effect of amide protoporphyrin derivatives on immune response in Apis mellifera
Trytek, Mariusz; Buczek, Katarzyna; Zdybicka-Barabas, Agnieszka; Wojda, Iwona; Borsuk, Grzegorz; Cytryńska, Małgorzata; Lipke, Agnieszka; Gryko, Dorota (Springer Nature, 2022)The intracellular microsporidian parasite Nosema ceranae is known to compromise bee health by induction of energetic stress and downregulation of the immune system. Porphyrins are candidate therapeutic agents for controlling ... -
Photochemical cyclopropanation in aqueous micellar media – experimental and theoretical studies
Milton, Joseph P.; Milanowski, Adam; Andersson, Martin; Gryko, Dorota (Royal Society of Chemistry, 2024)While in nature, reactions occur in water-based confined compartments, for a long time, water has been often regarded as an unsuitable medium for organic reactions. We have, however, found that photochemical cyclopropanation ... -
Porphyrins as Promising Photocatalysts for Red-Light-Induced Functionalizations of Biomolecules
Rybicka-Jasińska, Katarzyna; Wdowik, Tomasz; Łuczak, Klaudia; Wierzba, Aleksandra J.; Drapała, Olga; Gryko, Dorota (American Chemical Society, 2022)Red-light enables deeper material penetration, which is important for biological applications and has consequences for chemical synthesis. Therefore, the search for new photocatalysts that absorb in this region is crucial. ... -
Pyridine N-oxides as HAT reagents for photochemical C–H functionalization of electron-deficient heteroarenes
Ciszewski, Łukasz W.; Gryko, Dorota (Royal Society of Chemistry, 2022)Pyridine N-oxides have only recently marked their presence in the photocatalysis field, mainly serving as oxypyridinium salt precursors. Herein, their unique reactivity as a hydrogen atom transfer reagent in photochemical, ... -
Site-Selective, Photocatalytic Vinylogous Amidation of Enones
Szabó, Kitti Franciska; Goliszewska, Katarzyna; Szurmak, Jakub; Rybicka-Jasińska, Katarzyna; Gryko, Dorota (American Chemical Society, 2022)Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation ... -
Unlocking the reactivity of diazo compounds in red light with the use of photochemical tools
Orłowska, Katarzyna; Łuczak, Klaudia; Krajewski, Piotr; Santiago, João V.; Rybicka-Jasińska, Katarzyna; Gryko, Dorota (Royal Society of Chemistry, 2023)Structurally diversified diazoalkanes can be activated under red light irradiation relying on direct photolysis, photosensitization or photoredox catalysis. -
UV Light Is No Longer Required for the Photoactivation of 1,3,4- Oxadiazolines
Orłowska, Katarzyna; Santiago, João V.; Krajewski, Piotr; Kisiel, Kacper; Deperasińska, Irena; Zawada, Katarzyna; Chaładaj, Wojciech; Gryko, Dorota (American Chemical Society, 2023)Carbenes play a key role in a plethora of organic transformations. Although stabilized diazo carbonyl compounds predominate as a source of electrophilic carbenes, the hazardous nature of nonstabilized analogues calls for ... -
Vitamin B12 and a metal–organic framework enable the photocatalytic generation of alkyl radicals
Dworakowski, Krzysztof R.; Chołuj, Artur; Chmielewski, Michał J.; Gryko, Dorota (Royal Society of Chemistry, 2023)A versatile Co-catalyst-vitamin B12 (cobalamin)-can be photochemically reduced to its catalytically active Co(I) formunder visible light irradiation, in the presence of MIL-125-NH2(Ti) as a photocatalyst and utilized for ... -
Vitamin B12: An efficient cobalt catalyst for sustainable generation of radical species
Giedyk, Maciej; Gryko, Dorota (Elsevier, 2022)Vitamins are organic molecules that are essential for the proper functioning of mammalian cells. Among them, there is only one organometallic molecule: vitamin B12, a natural cobalt complex that is involved in DNA synthesis ...